منابع مشابه
Is Hemophilia ? Present Concepts of Hemophilia
By ALFREDO PAVLOVSKY, M.D. I F WE CONSIDER the classical definitions of hemophilia, which is described as an “hemorrhagic hereditary disease, of recessive character, linked to sex, surifered by males and transmitted by females, distinguished by a delayed (‘lottinig time arid with a characteristic hemorrhagic clinical picture,” we must admit that -some of these concepts has-c recently required m...
متن کاملHemophilia ? Hemophilia : Specific Entity or Syndrome ?
TUI)IES OF HEMOPHILIA have, ins the past-, helped greatly to solve the mansy intricacies of the blood coagulation mechanism. More recently, howeser, they have also altered our s-cry (‘onscept of the disease arid stnggested that, ins-stead of a svehl defined entity, hemophilia ins fact represents a syndrome siit.h many different pathogensetic mechanisms. The questions “ i’hat. is hemophihia?” is...
متن کاملHemophilia Pseudotumor.
Hemophilic pseudotumor or “blood cysts”, described by Starker1 are a rare complication of Hemophilia, observed in only 1-2% of patients with severe disease,2 consisting of extravasated clotted blood surrounded by a fibrous capsule. It affects bones, lungs, and abdomen and stomach wall. Morbidity occurs by compression on surrounding structures including bone destruction, muscle and skin necrosis...
متن کاملRecent Advances in Hemophilia Gene Therapy
Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...
متن کاملCanine Hemophilia
A study was made of the clotting defect and the course of the malady in a group of male dogs with an inherited, sex-linked bleeding disease. The clotting defect is characterized by a prolonged clotting time and a delayed prothrombin utilization, and is corrected by the addition either of thromboplastin or of normal plasma. A plasma protein fraction, fraction I, also corrects the defect. The def...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1897
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm189703111361002